Biochemists
have used a combination of biochemistry & mass spec to “trap” new
candidate substrates of the protease ClpXP to reveal how protein
degradation is critical to cell cycle progression and bacterial
development.
The bacterium Caulobacter crescentus (top image) was
used for this work. It generates radically different cell types upon
division. The ClpXP protease (bottom image) recognizes and destroys many protein substrates that allow Caulobacter to differentiate into these different cell types.
Read more on this work: http://bit.ly/10Cmd8u
Journal article: Identification of ClpP substrates in Caulobacter
crescentus reveals a role for regulated proteolysis in bacterial
development. Molecular Microbiology, 2013 DOI: 10.1111/mmi.12241
Image credit: Peter Chien, UMass Amherst
Biochemists
have used a combination of biochemistry & mass spec to “trap” new
candidate substrates of the protease ClpXP to reveal how protein
degradation is critical to cell cycle progression and bacterial
development.
The bacterium Caulobacter crescentus (top image) was used for this work. It generates radically different cell types upon division. The ClpXP protease (bottom image) recognizes and destroys many protein substrates that allow Caulobacter to differentiate into these different cell types.
Read more on this work: http://bit.ly/10Cmd8u
Journal article: Identification of ClpP substrates in Caulobacter crescentus reveals a role for regulated proteolysis in bacterial development. Molecular Microbiology, 2013 DOI: 10.1111/mmi.12241
Image credit: Peter Chien, UMass Amherst
The bacterium Caulobacter crescentus (top image) was used for this work. It generates radically different cell types upon division. The ClpXP protease (bottom image) recognizes and destroys many protein substrates that allow Caulobacter to differentiate into these different cell types.
Read more on this work: http://bit.ly/10Cmd8u
Journal article: Identification of ClpP substrates in Caulobacter crescentus reveals a role for regulated proteolysis in bacterial development. Molecular Microbiology, 2013 DOI: 10.1111/mmi.12241
Image credit: Peter Chien, UMass Amherst
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