You ain't no loser if you have the spark within you!
Well yes, but by losers I mean "loser cells" and by spark what I really mean is the SPARC protein (not good with puns).
And "loser cells" is how certain weak or malformed cells are termed
whose usual fate is apoptosis ( programmed cell death- PCD). There's
another term called Cell Competition, where, during development and
aging, animal cells
that have been
weakened by mutation, infection, and oxidative damage can be forced to
commit suicide by signals from healthy cells.
But in a 2010
study (Source 1), it was found that if a if a cell has suffered only a
temporary setback, say a transient transcription error, it can buy time
by expressing a survival factor, a protein called SPARC. (Source 4). The
study was done on Drosophila, and it described how unexpected existence
of a physiological mechanism was discovered that counteracts cell
competition during development.
In a 2011 study (Source 2),
this research was further expanded and it was discovered that the
expression of SPARC in human tumours/cancers is consistent with its role
during cell competition.
Although the exact role of SPARC is
yet to be ascertained, and it remains unknown whether this is the
central thing that SPARC does or are there many other things.
Source:
1) Portela M, Casas-Tinto S, Rhiner C, López-Gay JM, Domínguez O, Soldini D, Moreno E.
Dev Cell. 2010 Oct 19; 19(4):562-73
2) http://
3) http://www.sdbonline.org/fly/
4) http://www.the-scientist.com/
Image credit:
http://www.sciencedirect.com/
You ain't no loser if you have the spark within you!
Well yes, but by losers I mean "loser cells" and by spark what I really mean is the SPARC protein (not good with puns).
And "loser cells" is how certain weak or malformed cells are termed whose usual fate is apoptosis ( programmed cell death- PCD). There's another term called Cell Competition, where, during development and aging, animal cells
Well yes, but by losers I mean "loser cells" and by spark what I really mean is the SPARC protein (not good with puns).
And "loser cells" is how certain weak or malformed cells are termed whose usual fate is apoptosis ( programmed cell death- PCD). There's another term called Cell Competition, where, during development and aging, animal cells
that have been
weakened by mutation, infection, and oxidative damage can be forced to
commit suicide by signals from healthy cells.
But in a 2010 study (Source 1), it was found that if a if a cell has suffered only a temporary setback, say a transient transcription error, it can buy time by expressing a survival factor, a protein called SPARC. (Source 4). The study was done on Drosophila, and it described how unexpected existence of a physiological mechanism was discovered that counteracts cell competition during development.
In a 2011 study (Source 2), this research was further expanded and it was discovered that the expression of SPARC in human tumours/cancers is consistent with its role during cell competition.
Although the exact role of SPARC is yet to be ascertained, and it remains unknown whether this is the central thing that SPARC does or are there many other things.
Source:
1) Portela M, Casas-Tinto S, Rhiner C, López-Gay JM, Domínguez O, Soldini D, Moreno E.
Dev Cell. 2010 Oct 19; 19(4):562-73
2) http://
3) http://www.sdbonline.org/fly/
4) http://www.the-scientist.com/
Image credit:
http://www.sciencedirect.com/
But in a 2010 study (Source 1), it was found that if a if a cell has suffered only a temporary setback, say a transient transcription error, it can buy time by expressing a survival factor, a protein called SPARC. (Source 4). The study was done on Drosophila, and it described how unexpected existence of a physiological mechanism was discovered that counteracts cell competition during development.
In a 2011 study (Source 2), this research was further expanded and it was discovered that the expression of SPARC in human tumours/cancers is consistent with its role during cell competition.
Although the exact role of SPARC is yet to be ascertained, and it remains unknown whether this is the central thing that SPARC does or are there many other things.
Source:
1) Portela M, Casas-Tinto S, Rhiner C, López-Gay JM, Domínguez O, Soldini D, Moreno E.
Dev Cell. 2010 Oct 19; 19(4):562-73
2) http://
3) http://www.sdbonline.org/fly/
4) http://www.the-scientist.com/
Image credit:
http://www.sciencedirect.com/
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