Who’s in Charge Inside Your Head?
Zachary Zezima
By DAVID P. BARASH
Published: October 6, 2012
ZOMBIE bees?
That’s right: zombie bees. First reported in California in 2008, these
stranger-than-fiction creatures have spread to North Dakota and, just
recently, to my home in Washington State.
Of course, they’re not really zombies, although they act disquietingly
like them, showing abnormal behavior like flying at night (almost
unheard-of in healthy bees), moving erratically and then dying. These
“zombees” are victims of a parasitic fly, Apocephalus borealis. The fly
lays eggs within honeybees, inducing their hosts to make a nocturnal
“flight of the living dead,” after which the larval flies emerge, having
consumed the bee from the inside out.
These events, although bizarre, aren’t all that unusual in the animal
world. Many fly and wasp species lay their eggs inside hosts. What is
especially interesting, and a bit more unusual, is the way an internal
parasite not only feeds on its host, but also frequently alters its
behavior, in a way that favors the continued survival and reproduction
of the parasite.
Not all internal parasites kill their hosts, of course: pretty much
every multicellular animal is home to numerous fellow travelers, each of
which has its own agenda, which in some cases involves influencing, or
taking control of, part or all of the body in which they temporarily
reside.
And this, in turn, leads to the question: who’s in charge of your own
mind? Think of the morgue scene in the movie “Men in Black,” when a
human corpse is revealed to be a robot, its skull inhabited by a little
green man from outer space. Science fiction, but less bizarre than you
might expect, or want to believe.
Providing room and board to other life-forms doesn’t only compromise
one’s nutritional status (not to mention peace of mind), it often
reduces freedom of action, too. The technical phrase is “host
manipulation.”
Take the tapeworm Echinococcus multilocularis, which causes its mouse
host to become obese and sluggish, making it easy pickings for
predators, notably foxes, which — not coincidentally — provide an
optimal environment for the tapeworm to move into the next phase in its
life cycle.
Sometimes the process is truly strange. For example, a kind of fluke
known as Dicrocoelium dentriticum does time inside a snail, then an ant,
followed by a sheep. Ensconced within an ant, some of the resourceful
worms migrate to their host’s brain, where they manage to rewire its
neurons, essentially hijacking its body.
The manipulated ant, in response to Dicrocoelium’s demands, then climbs
to the top of a blade of grass and waits patiently and conspicuously
until it is consumed by a grazing sheep. Once in its desired happy
breeding ground, the worm releases its eggs, which depart with a healthy
helping of sheep poop, only to be consumed once more by snails, which
eventually excrete the immature worms for another generation of unlucky
ants to consume.
It may be distressing to those committed to “autonomy,” but such manipulators have inherited the earth. Including us.
Take coughing, or sneezing. It may be beneficial for an infected person
to cough up or sneeze out some of her tiny organismic invaders, although
it isn’t so healthful for others nearby. But what if coughing and
sneezing aren’t merely symptoms but also, even primarily, a manipulation
of us, the “host,” by influenza viruses? Shades of zombie bees,
fattened mice and grass-blade-besotted ants.
Just as Lenin urged us to ask “who, whom?” with regard to social
interactions — who benefits at the expense of whom? — the new science of
evolutionary medicine urges a similar question: who benefits when
people show symptoms of a disease? Often, it’s the critters that are
causing the disease in the first place.
But what about the daily, undiseased lives most of us experience?
Voluntary actions are, we like to insist, ours and ours alone, not for
the benefit of some parasitic or pathogenic occupying army. When we fall
in love, we do so for ourselves, not at the behest of a romance-addled
tapeworm. When we help a friend, we aren’t being manipulated by an
altruistic bacterium. If we eat when hungry, sleep when tired, scratch
an itch or write a poem, we aren’t knuckling under to the vices of our
viruses.
But it isn’t that simple.
Think about having a child, and ask who — or rather, what — benefits
from reproduction? It’s the genes. As modern biologists recognize,
babies are our genes’ way of projecting themselves into the future.
Unlike the cases of parasites or pathogens, when genes manipulate
“their” bodies, the situation seems less dire, if only because instead
of foreign occupation it’s our genes, our selves. But those presumably
personal genes aren’t any more hesitant about manipulating our bodies,
and by extension our actions, than is a parasitic fly hijacking a
honeybee.
Here, then, is heresy: maybe there is no one in charge — no independent,
self-serving, order-issuing homunculus. Buddhists note that our skin
doesn’t separate us from the environment, but joins us, just as
biologists know that “we” are manipulated by, no less than manipulators
of, the rest of life. Who is left after “you” are separated from your
genes? Where does the rest of the world end, and each of us begin?
Let’s leave the last words to a modern icon of organic, oceanic wisdom:
SpongeBob SquarePants. Mr. SquarePants, a cheerful, talkative — although
admittedly, somewhat cartoonish — fellow of the phylum Porifera, “lives
in a pineapple under the sea... Absorbent and yellow and porous is he.”
I don’t know about the pineapple or the yellow, but absorbent and
porous are we, too.
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